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This review provides a comprehensive overview of the interplay between vascular stability, CBF regulation, and vascular inflammation in the context of the BBB, with a particular emphasis on the dysfunction of these mechanisms in the pathophysiology of neurodegenerative diseases such as AD, PD, ALS, and MS

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A summary of clinical trials to include drug, dosing strategy, sample size, primary outcome measurements, risk reduction, date of publication, and conclusions is found in Table 1 [103,104,105,106,107,108,109,110,111,112]

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